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Did you know scientists discovered an “AHA” molecule inside the brains of people living with Dementia and the broader population in 1984, which we think is the primary culprit causing this devasting disease? We call this molecule Amyloid protein. In short, these molecules interfered with the connection and communication between the 86 billion neurons. But the story has just begun…

1984: Identifying amyloid-β in brain plaques (nature.com)

Hello, Dr Dennis here; you should know me by now; if not, please refer to my previous blogs, as I intend for all the blogs to flow as one whole story. Enough said, have you ever seen or heard about two contrasting groups of people both in their 80s or 90s? One group suffers from Alzheimer’s dementia, while the other group is the complete opposite. It defies logic and common sense. These questions baffled scientists and researchers but could not be answered confidently. We know some cases are genetically linked, but most aren’t. If you struggle to understand it all, I have good news! I will slowly unravel this for you; stay tuned! So,

What is Amyloid?

Figure One shows what a normal and an Alzheimer’s (the most common disease that will cause dementia) brain. Scientists know that amyloid plaques outside the neurons are aggregations of these insoluble plaques that the brain has difficulty clearing. But the real question is, why and what causes and why some people never develop Alzheimer’s despite having these plaques as well. Tangles are another culprit found inside the neurons. Figure Two is the picture of Amyloid plaques under the microscopes.

What are the possible solutions?

Given that we are unsure about the causes except the consequences, there are only four possible solutions (see slide above). Sadly, solution A is not achievable (until now…), B and C have achieved variable results, and D is the only partial solution. At best, we have only achieved symptomatic control, not reversibility or treatment.

So, what practical messages can you take away from this theory?

  • Amyloid protein is a naturally occurring molecule in every human’s brain. Amyloid protein is not all bad, but why some have more, and others have less is unknown.
  • Take heart. If we find the reasons, there is increasing clinical evidence that amyloid protein may be a “reactive” phenomenon.

If you are still confused, want to talk, or have more questions, email us at info@primegardensrs.com.au. Or, as usual, you are welcome to call Prime Garden Mont Albert North on (03) 98904488, leave a message, and our responsive staff will get back to you.

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